The Relationship Between Sinoatrial Conduction Time and Sinus Cycle Length Revisited

In 1974 we reported an inverse relationship between sinoatrial conduction time (SACT) and sinus cycle length (SCL) during sinus arrhythmia utilizing the indirect atrial premature stimulation technique for estimating SACT, However, this behavior seemed anomalous try analogy with the AV node. Subsequent to 1974, methodological considerations about and limitations of the indirect techniques for estimating SACT became apparent, making us question our former impression. When the capability to directly record sinus node electrograms was developed and established in the 1980s, we had the means to reevaluate the SACT/SCL relationship. This report presents our findings in 40 patients: the SACT/SCL relationship is direct, not inverse. Moreover, we also show that during the phasic fluctuations of sinus arrhythmia, the P-P alterations are initiated more frequently by changes in sinoatrial conduction time than by changes in sinus cycle length.     

从痰瘀论治妇科杂病举隅

痰饮与瘀血既是病理产物，又是致病因素，关系最为密切。病久入络，痰水挟瘀，交结为病。妇人若调摄不当，痰饮与瘀血留滞冲任、胞宫胞脉，可引发妇科杂病的发生。因此在针对疾病病机制定妇科杂病的相应治法时，应考虑痰瘀互结的影响，选用相应药物以提高临床疗效。     

近年来有关经络实质假说的文献综述

通过研读１９９２年以来国内主要期刊发表的有关经验实质假说的文献，并进行分析和归纳，总结出当前的几种主要观点，即神经说、血管神经说、生物物理观和生物化学观等。     

乳腺癌乳晕下亚甲兰注射检测哨兵淋巴结的临床研究

目的　评价乳晕下亚甲兰注射检测乳腺癌哨兵淋巴结。　方法　 2 0例早期乳腺癌患者应用亚甲兰乳晕下注射检测哨兵淋巴结。　结果　哨兵淋巴结检出率 95 % (19/ 2 0 )。预测腋窝淋巴结转移准确率为 94 7% (18/ 19)。　结论　乳晕下注射染料检测哨兵淋巴结为最佳途径 ,亚甲兰可以用于哨兵淋巴结检测。     

仙败合剂结合穴位埋线治疗慢性溃疡性结肠炎

为了研究中医治疗慢性溃疡性结肠炎的疗效,通过分析患者的资料,采用自拟仙败合剂结合穴位埋线疗法治疗慢性溃疡性结肠炎,辨证论治,疗效显著,值得临床推广使用.     

整体经络针刺法理论依据探讨

文章介绍了整体经络针刺法的取穴操作方法、适应症和立论依据。整体经络针刺法是在中医整体观念和经络学说指导下，根据十二经脉流注次序，每次针刺一条经脉相关腧穴，十二次针刺完所有十二经脉相关腧穴作为一疗程的针刺治疗方法。主要作用是整体上疏通十二经脉，全面调整各经脉、脏腑、系统的功能，临床上主要适用于辨证涉及多经脉、多脏腑、多系统，甚至十二经脉的病证。其立论依据主要是中医整体观、经络学说和经络整体性。     

Interaction of monovalent cations with tetrodotoxin and saxitoxin binding at sodium channels of frog myelinated nerve

Na currents and Na-current fluctuations were measured in myelinated frog nerve fibres to study interactions between monovalent externally applied cations and the binding of the Na-channel blockers tetrodotoxin (TTX) or saxitoxin (STX). Adding 110 mM NaCl to Ringer's solution increased the maximum peak Na conductance by a factor of 2.51 in the presence of 12 nM TTX and by a factor of 2.43 in the presence of 4 nM STX. According to the analysis of Na-current fluctuations this increase of the Na conductance is mainly caused by an increase of the number N of unblocked Na channels per node, while the conductance of a single channel saturates in the hyperosmolar solutions. The increase of N is interpreted by displacement of TTX or STX from Na channels by external Na⁺. Relief of TTX blockage was also observed by adding 100 mM chloride salts of Li⁺, hydrazine⁺, guanidine⁺ and K⁺ to Ringer, but not in Ringer + 110 mM tetramethylammonium chloride or 250 mM sucrose. The increase of N by the external cations is a saturating function of the permeability of the Na channel to these ions. The results are interpreted by a toxin receptor in a superficial prefilter to the Na channel, which contributes to cation discrimination at the outer channel region.     

Internal axonal cytoarchitecture is shaped locally by external compressive forces

The cross-sectional architecture of the axon and the area of its surrounding Schwann cell were quantified at selected histological regions along the length of avian myelinated axons. The number of neurofilaments (NFs), the density of NFs, axoplasmic area, and Schwann cell cross-sectional area were measured. These parameters were examined at Schmidt-Lanterman (S-L) clefts, at paranodal-nodal regions, and at regions of compact myelin Schwann cell nuclei. The results were then compared with the same parameters in adjacent compact myelinated regions of the same axons. At S-L clefts, paranodal-nodal regions, and Schwann cell nuclei, the axonal areas were smaller and the NF densities were higher than at compact myelinated regions. From other studies, it has been suggested that NF organization is responsive to local compressive forces — NF packing density tends to increase with increasing compression of the axon. We found that the NF packing densities were relatively small and the axon diameters were relatively large in the compact myelinated regions; this result suggests that in these axonal regions external constraints on axonal architecture are minimal. The higher NF packing densities and smaller axon diameters in the other histological regions suggest that external compressive effects on the axon increase in the following order: simple compact myelin < Schwann cell nucleus < S-L cleft < paranodal-nodal region. Ultrastructural comparisons of these 4 histological regions show that the Schwann cell cross-sectional areas differ reproducibly, and this is consistent with the idea that variations in the organization of extra-axonal elements that envelop the axon produce different amounts of physical constraint on the axon and that this can affect the amount of external pressure on the internal architecture of the axon.     

Clinical observation on scraping the Bladder Meridian for prevention and treatment of bronchial asthma

目的：观察刮痧防治支气管哮喘的临床疗效。方法：选择38例患者，每隔10～20d背部膀胱经刮痧治疗1次，每半年随访1次，连续随访3年，观察病人每年平均哮喘急性发作的次数。结果：患者刮痧前年均哮喘急性发作次数为（2．3±1．3）次，刮痧后降为0．6±0．4）次。结论：刮痧能有效预防支气管哮喘发作。     

中药复方治疗特发性肺间质纤维化的临床研究

目的 观察中药复方对特发性肺间质纤维化（IPF）的临床疗效.方法 将77例IPF患者随机分为治疗组与对照组,两组均按常规给予泼尼松、抗氧化剂口服,治疗组在此基础上予中药复方口服,两组疗程均为12周.观察、比较两组患者治疗前后临床症状、中医证候积分、肺功能及安全性指标.结果 两组临床疗效比较：治疗组总有效率71.42%,对照组37.14%,两组比较,差异有统计学意义（P＜0.05）.两组中医证候疗效比较：治疗组77.24%,对照组40.00%,两组比较,差异有统计学意义（P＜0.05）.两组肺功能比较：治疗组治疗后用力肺活量（FVC）、肺一氧化碳弥散量（DLCO）明显改善,与治疗前比较,差异有统计学意义（P＜0.05）,且治疗组优于对照组（P＜0.05）.两组动脉氧分压（PaO2）较治疗前也有升高,但差异无统计学意义（P＞0.05）.结论 中药复方能够改善IPF患者的临床症状、中医证候及肺功能,对于治疗IPF有一定作用.